Sandbox reserved 916: Difference between revisions

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====Binding====

The <scene name='58/580299/Ligand_binding_pocket/2'> ligand binding pocket </scene> of MGL has a large hydrophobic region with a polar bottom (Bertrand et al. 2010). Bertrand found that in MGL the binding pocket is not adjusted to the ligands shape. 2-archidonylglycerol are ligands for cannabinoid receptors (Clemente et al. 2012). Inhibition of MGL leads to increase in 2-AG levels since AG is broken down by MGL (Clemente et al. 2012). Through covalent interactions with a Cys residue, NAM, one of the many possible inhibitors, is able to inhibit MGL (Bertrand et al. 2010).

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[[Image:Overall_ligand.png|left|250px|thumb|Ligand within the Overall Structure of MGL]]

<scene name='58/580298/Ligand/1'>Ligand binding site</scene>

The <scene name='58/580299/Ligand_binding_pocket_take_3/1'> ligand binding pocket </scene> of MGL has a large hydrophobic region with a polar bottom (Bertrand et al. 2010). Bertrand found that in MGL the binding pocket is not adjusted to the ligands shape. 2-archidonylglycerol are ligands for cannabinoid receptors (Clemente et al. 2012). Inhibition of MGL leads to increase in 2-AG levels since AG is broken down by MGL (Clemente et al. 2012). Through covalent interactions with a Cys residue, NAM, one of the many possible inhibitors, is able to inhibit MGL (Bertrand et al. 2010).

==Overall Reaction==

Sandbox reserved 916: Difference between revisions

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@@ Line 21: / Line 21: @@
 ====Binding====
-The <scene name='58/580299/Ligand_binding_pocket/2'> ligand binding pocket </scene> of MGL has a large hydrophobic region with a polar bottom (Bertrand et al. 2010).  Bertrand found that in MGL the binding pocket is not adjusted to the ligands shape.  2-archidonylglycerol are ligands for cannabinoid receptors (Clemente et al. 2012).  Inhibition of MGL leads to increase in 2-AG levels since AG is broken down by MGL (Clemente et al. 2012).  Through covalent interactions with a Cys residue, NAM, one of the many possible inhibitors, is able to inhibit MGL (Bertrand et al. 2010).
@@ Line 27: / Line 26: @@
 [[Image:Overall_ligand.png|left|250px|thumb|Ligand within the Overall Structure of MGL]]
 <scene name='58/580298/Ligand/1'>Ligand binding site</scene>
+The <scene name='58/580299/Ligand_binding_pocket_take_3/1'> ligand binding pocket </scene> of MGL has a large hydrophobic region with a polar bottom (Bertrand et al. 2010).  Bertrand found that in MGL the binding pocket is not adjusted to the ligands shape.  2-archidonylglycerol are ligands for cannabinoid receptors (Clemente et al. 2012).  Inhibition of MGL leads to increase in 2-AG levels since AG is broken down by MGL (Clemente et al. 2012).  Through covalent interactions with a Cys residue, NAM, one of the many possible inhibitors, is able to inhibit MGL (Bertrand et al. 2010).
 ==Overall Reaction==