3ufy: Difference between revisions
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{{STRUCTURE_3ufy| PDB=3ufy | SCENE= }} | {{STRUCTURE_3ufy| PDB=3ufy | SCENE= }} | ||
===AKR1C3 complex with R-naproxen=== | ===AKR1C3 complex with R-naproxen=== | ||
{{ABSTRACT_PUBMED_22937138}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | |||
==About this Structure== | ==About this Structure== | ||
[[3ufy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3ufy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UFY OCA]. | ||
[[Category: | |||
==See Also== | |||
*[[Prostaglandin F synthase|Prostaglandin F synthase]] | |||
==Reference== | |||
<ref group="xtra">PMID:022937138</ref><references group="xtra"/><references/> | |||
[[Category: Human]] | |||
[[Category: Chai, M.]] | [[Category: Chai, M.]] | ||
[[Category: Flanagan, J U.]] | [[Category: Flanagan, J U.]] | ||
Revision as of 06:37, 26 March 2014
AKR1C3 complex with R-naproxen
Template:ABSTRACT PUBMED 22937138
Function
[AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
About this Structure
3ufy is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See Also
Reference
- Flanagan JU, Yosaatmadja Y, Teague RM, Chai MZ, Turnbull AP, Squire CJ. Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3. PLoS One. 2012;7(8):e43965. doi: 10.1371/journal.pone.0043965. Epub 2012 Aug 28. PMID:22937138 doi:https://dx.doi.org/10.1371/journal.pone.0043965
