4f22: Difference between revisions
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{{STRUCTURE_4f22| PDB=4f22 | SCENE= }} | {{STRUCTURE_4f22| PDB=4f22 | SCENE= }} | ||
===Kainate bound to the K660A mutant of the ligand binding domain of GluA3=== | ===Kainate bound to the K660A mutant of the ligand binding domain of GluA3=== | ||
{{ABSTRACT_PUBMED_22512472}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). | |||
==About this Structure== | |||
[[4f22]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F22 OCA]. | |||
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== | ==See Also== | ||
[[ | *[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]] | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022512472</ref><references group="xtra"/> | <ref group="xtra">PMID:022512472</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Buffalo rat]] | ||
[[Category: Ahmed, A H.]] | [[Category: Ahmed, A H.]] | ||
[[Category: Oswald, R E.]] | [[Category: Oswald, R E.]] | ||
Revision as of 08:12, 26 March 2014
Kainate bound to the K660A mutant of the ligand binding domain of GluA3
Template:ABSTRACT PUBMED 22512472
Function
[GRIA3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
About this Structure
4f22 is a 1 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.
See Also
Reference
- Holley SM, Ahmed AH, Srinivasan J, Murthy SE, Weiland GA, Oswald RE, Nowak LM. The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry. 2012 May 15;51(19):4015-27. Epub 2012 May 2. PMID:22512472 doi:10.1021/bi3001837
