4oda: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4oda| PDB=4oda | SCENE= }} | |||
===Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminus=== | |||
{{ABSTRACT_PUBMED_24603707}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/UNG_VACCC UNG_VACCC]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA (By similarity). [[http://www.uniprot.org/uniprot/A20_VACCC A20_VACCC]] Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein D4. May serve as a bridge which links the DNA polymerase E9 and the uracil DNA glycosylase (By similarity). | |||
==About this Structure== | |||
[[4oda]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODA OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024603707</ref><references group="xtra"/><references/> | |||
[[Category: Uracil-DNA glycosylase]] | |||
[[Category: Brazzolotto, X.]] | |||
[[Category: Burmeister, W P.]] | |||
[[Category: Contesto-Richefeu, C.]] | |||
[[Category: Iseni, F.]] | |||
[[Category: Tarbouriech, N.]] | |||
[[Category: Dna]] | |||
[[Category: Dna polymerase e9]] | |||
[[Category: Dna polymerase processivity factor]] | |||
[[Category: Hydrolase-replication complex]] | |||
Revision as of 09:17, 26 March 2014
Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminus
Template:ABSTRACT PUBMED 24603707
Function
[UNG_VACCC] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA (By similarity). [A20_VACCC] Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein D4. May serve as a bridge which links the DNA polymerase E9 and the uracil DNA glycosylase (By similarity).
About this Structure
4oda is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Contesto-Richefeu C, Tarbouriech N, Brazzolotto X, Betzi S, Morelli X, Burmeister WP, Iseni F. Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit d4 in complex with the a20 N-terminal domain. PLoS Pathog. 2014 Mar 6;10(3):e1003978. doi: 10.1371/journal.ppat.1003978., eCollection 2014 Mar. PMID:24603707 doi:https://dx.doi.org/10.1371/journal.ppat.1003978
