4j7f: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy===

~~The entry 4j7f~~ is ~~ON HOLD until Mar 26 2015~~

==Function==

[[http://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN]] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref> <ref>PMID:15099517</ref> <ref>PMID:16141209</ref> <ref>PMID:17108971</ref> <ref>PMID:12540855</ref> <ref>PMID:15525938</ref> [[http://www.uniprot.org/uniprot/TAF10_HUMAN TAF10_HUMAN]] TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

~~Authors~~: ~~Horowitz, S., Del Rizzo, P~~.A.~~, Trievel, R~~.C.

==About this Structure==

[[4j7f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7F OCA].

~~Description~~: ~~SET7/9Y335pAF in~~ complex ~~with TAF10 peptide and AdoHcy~~

==Reference==

[[Category: Histone-lysine N-methyltransferase]]

[[Category: Horowitz, S.]]

[[Category: Rizzo, P A.Del.]]

[[Category: Trievel, R C.]]

[[Category: Lysine methyltransferase]]

[[Category: Set domain]]

[[Category: Transferase-peptide complex]]

[[Category: Y335paf mutation]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4j7f|  PDB=4j7f  |  SCENE=  }}
+===SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy===
-The entry 4j7f is ON HOLD  until Mar 26 2015
+==Function==
+[[http://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN]] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref> <ref>PMID:15099517</ref> <ref>PMID:16141209</ref> <ref>PMID:17108971</ref> <ref>PMID:12540855</ref> <ref>PMID:15525938</ref>  [[http://www.uniprot.org/uniprot/TAF10_HUMAN TAF10_HUMAN]] TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
-Authors: Horowitz, S., Del Rizzo, P.A., Trievel, R.C.
+==About this Structure==
+[[4j7f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7F OCA].
-Description: SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Histone-lysine N-methyltransferase]]
+[[Category: Horowitz, S.]]
+[[Category: Rizzo, P A.Del.]]
+[[Category: Trievel, R C.]]
+[[Category: Lysine methyltransferase]]
+[[Category: Set domain]]
+[[Category: Transferase-peptide complex]]
+[[Category: Y335paf mutation]]