4js8: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4js8|  PDB=4js8  |  SCENE=  }}
===Crystal structure of TTK kinase domain with an inhibitor: 401348===


The entry 4js8 is ON HOLD
==Function==
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> 


Authors: Qiu, W., Plotnikov, A.N., Plotnikova, O., Feher, M., Awrey, D.E., Chirgadze, N.Y.
==About this Structure==
[[4js8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS8 OCA].  


Description: Crystal structure of TTK kinase domain with an inhibitor: 401348
==Reference==
<references group="xtra"/><references/>
[[Category: Dual-specificity kinase]]
[[Category: Awrey, D E.]]
[[Category: Chirgadze, N Y.]]
[[Category: Feher, M.]]
[[Category: Plotnikov, A N.]]
[[Category: Plotnikova, O.]]
[[Category: Qiu, W.]]
[[Category: Transferase-transferase inhibitor complex]]