4nst: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride===

~~The entry 4nst is ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.

~~Authors~~: ~~Boesken, C~~.A., ~~Farnung~~, L., ~~Anand, K~~., ~~Geyer, M~~.

==Function==

[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.<ref>PMID:11683387</ref> <ref>PMID:19651820</ref> <ref>PMID:20952539</ref> [[http://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN]] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref>

~~Description~~: ~~Crystal structure of human Cdk12~~/~~Cyclin~~ K in complex ~~with ADP-aluminum fluoride~~

==About this Structure==

[[4nst]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NST OCA].

==Reference==

[[Category: Anand, K.]]

[[Category: Boesken, C A.]]

[[Category: Farnung, L.]]

[[Category: Geyer, M.]]

[[Category: Phosphorylation]]

[[Category: Rna polymerase ii]]

[[Category: Transcription]]

[[Category: Transferase-transcription complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4nst|  PDB=4nst  |  SCENE=  }}
+===Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride===
-The entry 4nst is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.
-Authors: Boesken, C.A., Farnung, L., Anand, K., Geyer, M.
+==Function==
+[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.<ref>PMID:11683387</ref> <ref>PMID:19651820</ref> <ref>PMID:20952539</ref>  [[http://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN]] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref>
-Description: Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride
+==About this Structure==
+[[4nst]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NST OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Anand, K.]]
+[[Category: Boesken, C A.]]
+[[Category: Farnung, L.]]
+[[Category: Geyer, M.]]
+[[Category: Phosphorylation]]
+[[Category: Rna polymerase ii]]
+[[Category: Transcription]]
+[[Category: Transferase-transcription complex]]