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==Introduction to Hormone-Sensitive Lipase==
==Introduction to hormone-sensitive lipase==
[[Image:HPL_Movie0006.png|300 px|left|thumb|Hormone-Sensitive Lipase]]
[[Image:HPL_Movie0006.png|300 px|left|thumb|Hormone-Sensitive Lipase]]


Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] represent a class of esterases within the hydrolase class that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin]. <ref name="Nam">PMID:19089974</ref>
Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] represent a class of esterases within the hydrolase family that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin]. Briefly, binding of catecholamines to β-adrenergic receptors coupled with [http://www.proteopedia.org/wiki/index.php/Adenylate_Cyclase adenylate cyclase] (AC) stimulates G-proteins to increase the levels of cystolic [http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate cAMP]. Elevated levels of cAMP leads to an activation [http://www.proteopedia.org/wiki/index.php/Protein_kinase_A protein kinase A] (PKA) leading to phosphorylation of serine residues on HSL activating and translocating HSL to lipid droplets for lipolysis. Conversely, insulin signaling decreases cystolic cAMP levels, resulting in a decreased HSL mobilization. <ref name="Holm">PMID:14641008</ref>




Anything in this section will appear adjacent to the 3D structure and will be scrollable.
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==Structure of hormone-sensitive lipase==


==Structure of Hormone-Sensitive Lipase==
<ref name="Nam">PMID:19089974</ref>


<StructureSection load='3DNM' size='350' frame='true' align='right' caption='Hormone-Sensitive Lipase from [[3dnm]]' scene='58/580297/3dnm_cartoon/2' >
<StructureSection load='3DNM' size='350' frame='true' align='right' caption='Hormone-Sensitive Lipase from [[3dnm]]' scene='58/580297/3dnm_cartoon/2' >
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