Sandbox reserved 915: Difference between revisions
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MGL is also inhibited by being in complex with SAR629 that is covalently bound to the catalytic Ser132. SAR629 adopts a Y shape and interacts with the MGL by hydrophobic interactions, with a few polar interactions as well. With SAR629 interacting with the catalytic triad it inhibits the triad from breaking down 2-AG and it interacting with MGL makes it inactive. | MGL is also inhibited by being in complex with SAR629 that is covalently bound to the catalytic Ser132. SAR629 adopts a Y shape and interacts with the MGL by hydrophobic interactions, with a few polar interactions as well. With SAR629 interacting with the catalytic triad it inhibits the triad from breaking down 2-AG and it interacting with MGL makes it inactive. | ||
==Structure== | ==Structure== | ||
Representation of the <scene name='58/580298/Overall_structure/3'>Overall Structure</scene> | Representation of the <scene name='58/580298/Overall_structure/3'>Overall Structure</scene> MGL has eight-stranded β-sheet protein fold with seven parallel and one <scene name='58/580299/Beta_sheets/1'> antiparallel strand </scene> (Bertrand et al. 2010). | ||
== Catalytic triad == | == Catalytic triad == | ||
