9hvp: Difference between revisions

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[[Image:9hvp.gif|left|200px]]<br />

[[Image:9hvp.gif|left|200px]]<br /><applet load="9hvp" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="9hvp" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="9hvp, resolution 2.8Å" />

'''DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE'''<br />

==Overview==

A two-fold (C2) symmetric inhibitor of the protease of human, immunodeficiency virus type-1 (HIV-1) has been designed on the basis of, the three-dimensional symmetry of the enzyme active site. The symmetric, molecule inhibited both protease activity and acute HIV-1 infection in, vitro, was at least 10,000-fold more potent against HIV-1 protease than, against related enzymes, and appeared to be stable to degradative enzymes., The 2.8 angstrom crystal structure of the inhibitor-enzyme complex, demonstrated that the inhibitor binds to the enzyme in a highly symmetric, fashion.

A two-fold (C2) symmetric inhibitor of the protease of human immunodeficiency virus type-1 (HIV-1) has been designed on the basis of the three-dimensional symmetry of the enzyme active site. The symmetric molecule inhibited both protease activity and acute HIV-1 infection in vitro, was at least 10,000-fold more potent against HIV-1 protease than against related enzymes, and appeared to be stable to degradative enzymes. The 2.8 angstrom crystal structure of the inhibitor-enzyme complex demonstrated that the inhibitor binds to the enzyme in a highly symmetric fashion.

==About this Structure==

9HVP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with PHQ as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=9HVP OCA].

9HVP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PHQ:'>PHQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HVP OCA].

==Reference==

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[[Category: Single protein]]

[[Category: Erickson, J.]]

[[Category: Neidhart, D.J.]]

[[Category: Neidhart, D J.]]

[[Category: PHQ]]

[[Category: hydrolase(acid proteinase)]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on Thu ~~Nov 8 14~~:59:~~51 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:18:34 2008''

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@@ Line 1: / Line 1: @@
-[[Image:9hvp.gif|left|200px]]<br />
+[[Image:9hvp.gif|left|200px]]<br /><applet load="9hvp" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="9hvp" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="9hvp, resolution 2.8&Aring;" />
 '''DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE'''<br />
 ==Overview==
-A two-fold (C2) symmetric inhibitor of the protease of human, immunodeficiency virus type-1 (HIV-1) has been designed on the basis of, the three-dimensional symmetry of the enzyme active site. The symmetric, molecule inhibited both protease activity and acute HIV-1 infection in, vitro, was at least 10,000-fold more potent against HIV-1 protease than, against related enzymes, and appeared to be stable to degradative enzymes., The 2.8 angstrom crystal structure of the inhibitor-enzyme complex, demonstrated that the inhibitor binds to the enzyme in a highly symmetric, fashion.
+A two-fold (C2) symmetric inhibitor of the protease of human immunodeficiency virus type-1 (HIV-1) has been designed on the basis of the three-dimensional symmetry of the enzyme active site. The symmetric molecule inhibited both protease activity and acute HIV-1 infection in vitro, was at least 10,000-fold more potent against HIV-1 protease than against related enzymes, and appeared to be stable to degradative enzymes. The 2.8 angstrom crystal structure of the inhibitor-enzyme complex demonstrated that the inhibitor binds to the enzyme in a highly symmetric fashion.
 ==About this Structure==
-HVP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with PHQ as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=9HVP OCA].
+HVP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PHQ:'>PHQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HVP OCA].
 ==Reference==
@@ Line 15: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Erickson, J.]]
-[[Category: Neidhart, D.J.]]
+[[Category: Neidhart, D J.]]
 [[Category: PHQ]]
 [[Category: hydrolase(acid proteinase)]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 14:59:51 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:18:34 2008''