Sandbox reserved 919: Difference between revisions
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[[Image:HPL_Movie0006.png|300 px|left|thumb|Hormone-Sensitive Lipase]] | [[Image:HPL_Movie0006.png|300 px|left|thumb|Hormone-Sensitive Lipase]] | ||
Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] (HSL) represent a class of esterases within the hydrolase family that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin]. HSL is clinically relevant because the mobilization of fats in cells is directly related to fat accumulation seen in atherosclerosis, diabetes, and obesity. Investigation of HSL's structure and function could provide a better clinical understanding of these diseases. <ref name= "Yeaman">PMID:14725507</ref> | Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] (HSL) represent a class of [http://en.wikipedia.org/wiki/Esterase esterases] within the [http://www.proteopedia.org/wiki/index.php/Hydrolase hydrolase] family that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin]. HSL is clinically relevant because the mobilization of fats in cells is directly related to fat accumulation seen in atherosclerosis, diabetes, and obesity. Investigation of HSL's structure and function could provide a better clinical understanding of these diseases. <ref name= "Yeaman">PMID:14725507</ref> | ||
Briefly, binding of catecholamines to β-adrenergic receptors coupled with [http://www.proteopedia.org/wiki/index.php/Adenylate_Cyclase adenylate cyclase] (AC) stimulates G-proteins to increase the levels of cystolic [http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate cAMP]. Elevated levels of cAMP leads to an activation [http://www.proteopedia.org/wiki/index.php/Protein_kinase_A protein kinase A] (PKA) leading to phosphorylation of serine residues on HSL activating and translocating HSL to lipid droplets for lipolysis. Conversely, insulin signaling decreases cystolic cAMP levels, resulting in a decreased HSL mobilization. <ref name="Holm">PMID:14641008</ref> | Briefly, binding of catecholamines to β-adrenergic receptors coupled with [http://www.proteopedia.org/wiki/index.php/Adenylate_Cyclase adenylate cyclase] (AC) stimulates G-proteins to increase the levels of cystolic [http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate cAMP]. Elevated levels of cAMP leads to an activation [http://www.proteopedia.org/wiki/index.php/Protein_kinase_A protein kinase A] (PKA) leading to phosphorylation of serine residues on HSL activating and translocating HSL to lipid droplets for lipolysis. Conversely, insulin signaling decreases cystolic cAMP levels, resulting in a decreased HSL mobilization. <ref name="Holm">PMID:14641008</ref> | ||
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* [http://en.wikipedia.org/wiki/Hormone_sensitive_lipase Hormone-sensitive lipase] | * [http://en.wikipedia.org/wiki/Hormone_sensitive_lipase Hormone-sensitive lipase] | ||
* [http://proteopedia.org/wiki/index.php/Lipase Lipase] | * [http://proteopedia.org/wiki/index.php/Lipase Lipase] | ||
* [http://www.proteopedia.org/wiki/index.php/Category:Esterase Other esterases] | |||
==References== | ==References== | ||
<references /> | <references /> | ||
