Nucleoside diphosphate kinase: Difference between revisions
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'''Nucleoside diphosphate kinase''' (NDK) catalyzes the transfer of phosphate from nucleoside triphosphate to nucleoside diphosphate. This reaction is a multi-step reaction and is used for the synthesis of nucleoside triphosphates other than ATP. NDK provides nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule | '''Nucleoside diphosphate kinase''' (NDK) catalyzes the transfer of phosphate from nucleoside triphosphate to nucleoside diphosphate. This reaction is a multi-step reaction and is used for the synthesis of nucleoside triphosphates other than ATP. NDK provides nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, UTP for polysaccharide synthesis and GTP for protein elongation, signal transduction and microtubule polymerization. | ||
==3D structures of nucleoside diphosphate kinase== | ==3D structures of nucleoside diphosphate kinase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[1ndk]], [[1npk]], [[1s5z]] – DdNDK – ''Dictyostelium discoideum''<BR /> | [[1ndk]], [[1npk]], [[1s5z]] – DdNDK – ''Dictyostelium discoideum''<BR /> | ||
[[1nlk]] - DdNDK with phosphohistidine intermediate<BR /> | [[1nlk]], [[1nsp]] - DdNDK with phosphohistidine intermediate<BR /> | ||
[[1leo]], [[1ncl]], [[1hlw]], [[1hhq]], [[1pae]] - DdNDK (mutant) <BR /> | [[1leo]], [[1ncl]], [[1hlw]], [[1hhq]], [[1pae]], [[4c6a]] - DdNDK (mutant) <BR /> | ||
[[2nck]] – MxNDK – ''Myxococcus xanthus''<BR /> | [[2nck]] – MxNDK – ''Myxococcus xanthus''<BR /> | ||
[[1ndl]] – DmNDK – ''Drosophila melanogaster''<BR /> | [[1ndl]] – DmNDK – ''Drosophila melanogaster''<BR /> | ||
[[1nsq]] - DmNDK with phosphohistidine intermediate<BR /> | [[1nsq]] - DmNDK with phosphohistidine intermediate<BR /> | ||
[[1nsk]], [[1jxv]], [[3l7u]] - hNDK A – human<BR /> | [[1nsk]], [[1jxv]], [[3l7u]], [[4eno]] - hNDK A – human<BR /> | ||
[[1ehw]] - hNDK 4 (mutant) <BR /> | [[1ehw]] - hNDK 4 (mutant) <BR /> | ||
[[1k44]] – | [[3bbc]] - hNDK B (mutant)<br /> | ||
[[1k44]], [[4anc]] – MtNDK – ''Mycobacterium tuberculosis''<BR /> | |||
[[4and]], [[4ane]] - MtNDK (mutant)<br /> | |||
[[1nb2]] - NDK - ''Virgibacillus halodenitrificans''<BR /> | [[1nb2]] - NDK - ''Virgibacillus halodenitrificans''<BR /> | ||
[[1xiq]] - NDK A – ''Plasmodium falciparum''<BR /> | [[1xiq]] - NDK A – ''Plasmodium falciparum''<BR /> | ||
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[[4di6]] - BbNDK – ''Borrelia burgdorferi''<BR /> | [[4di6]] - BbNDK – ''Borrelia burgdorferi''<BR /> | ||
[[3ztq]], [[3zto]], [[3ztp]], [[3ztr]], [[3zts]] - NDK – ''Aquifex aeolicus''<BR /> | [[3ztq]], [[3zto]], [[3ztp]], [[3ztr]], [[3zts]] - NDK – ''Aquifex aeolicus''<BR /> | ||
[[4dut]] - | [[4dut]] - BtNDK – ''Burkholderia thailandensis''<br /> | ||
[[2cwk]] - PhNDK – ''Pyrococcus horikoshii''<br /> | |||
[[3vgs]], [[3vgt]] - HaNDK – ''Halomonas''<br /> | |||
[[3vgu]], [[3vgv]] - HaNDK (mutant)<br /> | |||
[[3vvt]] - NDK – reconstructed archaeal ancestral<br /> | |||
[[3vvu]] - NDK – reconstructed bacterial ancestral<br /> | |||
[[4f36]] – TbNDK – ''Trypanosoma brucei''<br /> | |||
'''NDK complex with adenine derivative''' | '''NDK complex with adenine derivative''' | ||
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[[1ucn]], [[2hve]] - hNDK (mutant) + ADP<BR /> | [[1ucn]], [[2hve]] - hNDK (mutant) + ADP<BR /> | ||
[[1zs6]] - hNDK 3 + ADP<BR /> | [[1zs6]] - hNDK 3 + ADP<BR /> | ||
[[2dxd]] - PhNDK + ATP analog | [[2dxd]] - PhNDK + ATP analog <BR /> | ||
[[2dy9]], [[2dya]] - PhNDK + ADP<BR /> | [[2dy9]], [[2dya]] - PhNDK + ADP<BR /> | ||
[[3ngt]] - LmNDK + AMP<BR /> | [[3ngt]] - LmNDK + AMP<BR /> | ||
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[[3q8u]], [[3q8y]] - SaNDK + ADP<BR /> | [[3q8u]], [[3q8y]] - SaNDK + ADP<BR /> | ||
[[4dz6]] - BbNDK + ADP<BR /> | [[4dz6]] - BbNDK + ADP<BR /> | ||
[[1wkl]] - TtNDK + ADP + ATP<br /> | |||
[[4ek2]] - BtNDK + AMP derivative<br /> | |||
[[4hr2]] - BtNDK + ADP<br /> | |||
'''NDK complex with thymidine derivative''' | '''NDK complex with thymidine derivative''' | ||
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[[3evm]] - ApNDK (mutant) + CDP derivative<br /> | [[3evm]] - ApNDK (mutant) + CDP derivative<br /> | ||
[[3q89]] - SaNDK + CDP<BR /> | [[3q89]] - SaNDK + CDP<BR /> | ||
[[4fkx]] - TbNDK + CDP<br /> | |||
'''NDK complex with guanine derivative''' | '''NDK complex with guanine derivative''' | ||
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[[3fcw]] - ApNDK (mutant) + UDP<BR /> | [[3fcw]] - ApNDK (mutant) + UDP<BR /> | ||
[[3q8v]] - SaNDK + UDP<BR /> | [[3q8v]] - SaNDK + UDP<BR /> | ||
[[4f4a]] - TbNDK + UDP<br /> | |||
[[1mn9]], [[3fkb]] - DdNDK (mutant) + antiviral drug | [[1mn9]], [[3fkb]] - DdNDK (mutant) + antiviral drug | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
