4js0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Complex of Cdc42 with the CRIB-PR domain of IRSp53===

~~The entry 4js0 is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref> [[http://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>

~~Authors~~: ~~Kast, D~~.J.~~, Dominguez, R~~.

==About this Structure==

[[4js0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS0 OCA].

~~Description~~: ~~Complex between Cdc42 and the IRSp53 CRIB~~-~~PR domain~~

==Reference==

[[Category: Dominguez, R.]]

[[Category: Kast, D J.]]

[[Category: Crib domain]]

[[Category: Cytoskeleton regulation]]

[[Category: Gtpase binding domain]]

[[Category: Signaling protein-signaling protein complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4js0|  PDB=4js0  |  SCENE=  }}
+===Complex of Cdc42 with the CRIB-PR domain of IRSp53===
+{{ABSTRACT_PUBMED_24584464}}
-The entry 4js0 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>  [[http://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN]] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>
-Authors: Kast, D.J., Dominguez, R.
+==About this Structure==
+[[4js0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS0 OCA].
-Description: Complex between Cdc42 and the IRSp53 CRIB-PR domain
+==Reference==
+<ref group="xtra">PMID:024584464</ref><references group="xtra"/><references/>
+[[Category: Dominguez, R.]]
+[[Category: Kast, D J.]]
+[[Category: Crib domain]]
+[[Category: Cytoskeleton regulation]]
+[[Category: Gtpase binding domain]]
+[[Category: Signaling protein-signaling protein complex]]