3eqy: Difference between revisions
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{{STRUCTURE_3eqy| PDB=3eqy | SCENE= }} | {{STRUCTURE_3eqy| PDB=3eqy | SCENE= }} | ||
===Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor=== | ===Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor=== | ||
{{ABSTRACT_PUBMED_19255450}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019255450</ref><references group="xtra"/> | <ref group="xtra">PMID:019255450</ref><references group="xtra"/><references/> | ||
[[Category: Lu, W.]] | [[Category: Lu, W.]] | ||
[[Category: Pazgier, M.]] | [[Category: Pazgier, M.]] | ||
