3en3: Difference between revisions
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{{STRUCTURE_3en3| PDB=3en3 | SCENE= }} | {{STRUCTURE_3en3| PDB=3en3 | SCENE= }} | ||
===Crystal Structure of the GluR4 Ligand-Binding domain in complex with kainate=== | ===Crystal Structure of the GluR4 Ligand-Binding domain in complex with kainate=== | ||
{{ABSTRACT_PUBMED_19102704}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GRIA4_RAT GRIA4_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).<ref>PMID:12603841</ref> <ref>PMID:19102704</ref> <ref>PMID:20107073</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3en3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3en3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EN3 OCA]. | ||
==See Also== | ==See Also== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019102704</ref><references group="xtra"/> | <ref group="xtra">PMID:019102704</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Buffalo rat]] | ||
[[Category: Gill, A.]] | [[Category: Gill, A.]] | ||
[[Category: Madden, D R.]] | [[Category: Madden, D R.]] | ||
