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<big>''Here's an excerpt from one of our pages:''</big> | <big>''Here's an excerpt from one of our pages:''</big> | ||
The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <b><font color='green'>unique orientation</font></b> along the active-site gorge, extending from the anionic subsite (<b><font color='green'>W84</font></b>) of the active site, at the bottom, to the peripheral anionic site (<b><font color='green'>near W279</font></b>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <b><font color='green'>indirectly via solvent molecules</font></b>. | The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <b><font color='green'>unique orientation</font></b> along the active-site gorge, extending from the anionic subsite (<b><font color='green'>W84</font></b>) of the active site, at the bottom, to the peripheral anionic site (<b><font color='green'>near W279</font></b>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <b><span onClick='getJava();'><font color='green' >indirectly via solvent molecules</font></span></b>. | ||
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You will find in this [[Proteopedia:Troubleshooting|Troubleshooting]] page help for enabling Java in your computer and start enjoying Proteopedia's features. | You will find in this [[Proteopedia:Troubleshooting|Troubleshooting]] page help for enabling Java in your computer and start enjoying Proteopedia's features. | ||
</big> | </big> | ||
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