4bvn: Difference between revisions
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{{STRUCTURE_4bvn| PDB=4bvn | SCENE= }} | |||
===Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound=== | |||
{{ABSTRACT_PUBMED_24663151}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. | |||
==About this Structure== | |||
[[4bvn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVN OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024663151</ref><references group="xtra"/><references/> | |||
[[Category: Edwards, P C.]] | |||
[[Category: Leslie, A G.W.]] | |||
[[Category: Miller, J.]] | |||
[[Category: Nehme, R.]] | |||
[[Category: Schertler, G.]] | |||
[[Category: Tate, C G.]] | |||
[[Category: Warne, T.]] | |||
[[Category: Signaling protein]] | |||
Revision as of 09:15, 2 April 2014
Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound
Template:ABSTRACT PUBMED 24663151
Function
[ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
About this Structure
4bvn is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Miller-Gallacher JL, Nehme R, Warne T, Edwards PC, Schertler GF, Leslie AG, Tate CG. The 2.1 A Resolution Structure of Cyanopindolol-Bound beta1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor. PLoS One. 2014 Mar 24;9(3):e92727. doi: 10.1371/journal.pone.0092727. eCollection, 2014. PMID:24663151 doi:https://dx.doi.org/10.1371/journal.pone.0092727
