4nud: Difference between revisions
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{{STRUCTURE_4nud| PDB=4nud | SCENE= }} | |||
===Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor=== | |||
{{ABSTRACT_PUBMED_24144283}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==About this Structure== | |||
[[4nud]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUD OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024144283</ref><references group="xtra"/><references/> | |||
[[Category: Joshua, J.]] | |||
[[Category: Plotnikov, A N.]] | |||
[[Category: Zhou, M M.]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription factor]] | |||
[[Category: Transcription-transcription inhibitor complex]] | |||
Revision as of 09:15, 2 April 2014
Crystal structure of the first bromodomain of human BRD4 in complex with MS436 inhibitor
Template:ABSTRACT PUBMED 24144283
Disease
[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]
Function
[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
About this Structure
4nud is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Zhang G, Plotnikov AN, Rusinova E, Shen T, Morohashi K, Joshua J, Zeng L, Mujtaba S, Ohlmeyer M, Zhou MM. Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. doi: 10.1021/jm401334s. Epub 2013 Nov 11. PMID:24144283 doi:https://dx.doi.org/10.1021/jm401334s
- ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
- ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0
