4p54: Difference between revisions

Line 1:

'~~''Unreleased structure'''~~

===Crystal Structure of the Helicobacter pylori MTAN-D198N mutant with 5'-methylthioadenosine in the active site.===

~~The entry 4p54 is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/MQMTN_HELPJ MQMTN_HELPJ]] Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species. Also catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Can also probably use S-adenosylhomocysteine (SAH) as substrate, leading to adenine and S-ribosylhomocysteine. These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2.<ref>PMID:20954236</ref> <ref>PMID:22891633</ref>

~~Authors~~: ~~Ronning, D~~.R.~~, Mishra, V~~

==About this Structure==

[[4p54]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P54 OCA].

~~Description~~: ~~Crystal Structure of the Helicobacter pylori MTAN-D198N mutant with 5-methylthioadenosine in the active site~~.

==Reference==

[[Category: Adenosylhomocysteine nucleosidase]]

[[Category: Mishra, V]]

[[Category: Ronning, D R.]]

[[Category: Homodimer]]

[[Category: Hydrolase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4p54|  PDB=4p54  |  SCENE=  }}
+===Crystal Structure of the Helicobacter pylori MTAN-D198N mutant with 5'-methylthioadenosine in the active site.===
+{{ABSTRACT_PUBMED_23148563}}
-The entry 4p54 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/MQMTN_HELPJ MQMTN_HELPJ]] Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Helicobacter species. Also catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Can also probably use S-adenosylhomocysteine (SAH) as substrate, leading to adenine and S-ribosylhomocysteine. These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2.<ref>PMID:20954236</ref> <ref>PMID:22891633</ref>
-Authors: Ronning, D.R., Mishra, V
+==About this Structure==
+[[4p54]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P54 OCA].
-Description: Crystal Structure of the Helicobacter pylori MTAN-D198N mutant with 5-methylthioadenosine in the active site.
+==Reference==
+<ref group="xtra">PMID:023148563</ref><references group="xtra"/><references/>
+[[Category: Adenosylhomocysteine nucleosidase]]
+[[Category: Mishra, V]]
+[[Category: Ronning, D R.]]
+[[Category: Homodimer]]
+[[Category: Hydrolase]]