4coh: Difference between revisions
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{{STRUCTURE_4coh| PDB=4coh | SCENE= }} | |||
===Crystal structure of Trypanosoma cruzi CYP51 bound to the sulfonamide derivative of the 4-aminopyridyl-based inhibitor=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CP51_TRYCC CP51_TRYCC]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref> [UniProtKB:P0A512] | |||
==About this Structure== | |||
[[4coh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4COH OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Sterol 14-demethylase]] | |||
[[Category: Choi, J Y.]] | |||
[[Category: Podust, L M.]] | |||
[[Category: Roush, W R.]] | |||
[[Category: Vieira, D F.]] | |||
[[Category: Chagas disease]] | |||
[[Category: Cyp51]] | |||
[[Category: Sterol 14-demethylase]] | |||
[[Category: Sterol biosynthesis]] | |||
[[Category: Transferase]] | |||
Revision as of 09:29, 2 April 2014
Crystal structure of Trypanosoma cruzi CYP51 bound to the sulfonamide derivative of the 4-aminopyridyl-based inhibitor
Function
[CP51_TRYCC] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.[1] [UniProtKB:P0A512]
About this Structure
4coh is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. J Biol Chem. 2006 Feb 10;281(6):3577-85. Epub 2005 Nov 30. PMID:16321980 doi:M510317200
