4edx: Difference between revisions

Line 1:

~~WITHDRAWN~~: The ~~PDB entry~~ 4EDX ~~was withdrawn~~.

===Nerve Growth Factor in Complex with Fab from mouse mAb 911===

==Disease==

[[http://www.uniprot.org/uniprot/NGF_HUMAN NGF_HUMAN]] Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:[http://omim.org/entry/608654 608654]]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.<ref>PMID:14976160</ref> <ref>PMID:20978020</ref> <ref>PMID:22302274</ref>

==Function==

[[http://www.uniprot.org/uniprot/NGF_HUMAN NGF_HUMAN]] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.

==About this Structure==

[[4edx]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDX OCA].

==Reference==

[[Category: Eigenbrot, C.]]

[[Category: Ultsch, M.]]

[[Category: Cystine knot]]

[[Category: Growth/survival factor]]

[[Category: Immune system]]

[[Category: Immunoglobulin]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-WITHDRAWN: The PDB entry 4EDX was withdrawn.
+{{STRUCTURE_4edx|  PDB=4edx  |  SCENE=  }}
+===Nerve Growth Factor in Complex with Fab from mouse mAb 911===
+==Disease==
+[[http://www.uniprot.org/uniprot/NGF_HUMAN NGF_HUMAN]] Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:[http://omim.org/entry/608654 608654]]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.<ref>PMID:14976160</ref> <ref>PMID:20978020</ref> <ref>PMID:22302274</ref>
+==Function==
+[[http://www.uniprot.org/uniprot/NGF_HUMAN NGF_HUMAN]] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.
+==About this Structure==
+[[4edx]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDX OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Eigenbrot, C.]]
+[[Category: Ultsch, M.]]
+[[Category: Cystine knot]]
+[[Category: Growth/survival factor]]
+[[Category: Immune system]]
+[[Category: Immunoglobulin]]