4jyw: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4jyw|  PDB=4jyw  |  SCENE=  }}
+===X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1057===
-The entry 4jyw is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/FOLH1_HUMAN FOLH1_HUMAN]] Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.  Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
-Authors: Barinka, C.
+==About this Structure==
+[[4jyw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYW OCA].
-Description: X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1057
+[[Category: Glutamate carboxypeptidase II]]
+[[Category: Barinka, C.]]
+[[Category: Hydrolase]]
+[[Category: Metallopeptidase]]

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