4po6: Difference between revisions
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{{STRUCTURE_4po6| PDB=4po6 | SCENE= }} | |||
===Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide=== | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> [[http://www.uniprot.org/uniprot/INAR1_HUMAN INAR1_HUMAN]] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. | |||
==About this Structure== | |||
[[4po6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PO6 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Non-specific protein-tyrosine kinase]] | |||
[[Category: Lupardus, P J.]] | |||
[[Category: Wallweber, H J.A.]] | |||
[[Category: Cytokine]] | |||
[[Category: Ferm]] | |||
[[Category: Intracellular]] | |||
[[Category: Kinase]] | |||
[[Category: Receptor]] | |||
[[Category: Sh2]] | |||
[[Category: Transferase]] | |||
Revision as of 09:41, 2 April 2014
Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide
Disease
[TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
Function
[TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.[1] [INAR1_HUMAN] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
About this Structure
4po6 is a 2 chain structure. Full crystallographic information is available from OCA.
