3f9y: Difference between revisions
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{{STRUCTURE_3f9y| PDB=3f9y | SCENE= }} | {{STRUCTURE_3f9y| PDB=3f9y | SCENE= }} | ||
===Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me1 / AdoHcy=== | ===Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me1 / AdoHcy=== | ||
{{ABSTRACT_PUBMED_19088188}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SETD8_HUMAN SETD8_HUMAN]] Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.<ref>PMID:12086618</ref> <ref>PMID:12121615</ref> <ref>PMID:15200950</ref> <ref>PMID:16517599</ref> <ref>PMID:17707234</ref> <ref>PMID:15933069</ref> <ref>PMID:15933070</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3f9y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3f9y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9Y OCA]. | ||
==See Also== | |||
*[[Histone methyltransferase|Histone methyltransferase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019088188</ref><references group="xtra"/> | <ref group="xtra">PMID:019088188</ref><references group="xtra"/><references/> | ||
[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
[[Category: | [[Category: Human]] | ||
[[Category: Brunzelle, J S.]] | [[Category: Brunzelle, J S.]] | ||
[[Category: Couture, J-F.]] | [[Category: Couture, J-F.]] | ||
