3sfi: Difference between revisions
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{{STRUCTURE_3sfi| PDB=3sfi | SCENE= }} | {{STRUCTURE_3sfi| PDB=3sfi | SCENE= }} | ||
===Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.=== | ===Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.=== | ||
{{ABSTRACT_PUBMED_22098589}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3sfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3sfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Uncultured_bacterium_'eubacterium_sp.' Uncultured bacterium 'eubacterium sp.']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFI OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022098589</ref><references group="xtra"/> | <ref group="xtra">PMID:022098589</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Uncultured bacterium 'eubacterium sp.']] | ||
[[Category: Baulard, A R.]] | [[Category: Baulard, A R.]] | ||
[[Category: Blondiaux, N.]] | [[Category: Blondiaux, N.]] | ||