4c58: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4c58| PDB=4c58 | SCENE= }} | {{STRUCTURE_4c58| PDB=4c58 | SCENE= }} | ||
===Structure of GAK kinase in complex with nanobody (NbGAK_4)=== | ===Structure of GAK kinase in complex with nanobody (NbGAK_4)=== | ||
{{ABSTRACT_PUBMED_24438162}} | |||
==Function== | ==Function== | ||
| Line 6: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
[[4c58]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4c58]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C58 OCA]. | ||
==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:024438162</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Allerston, C K.]] | [[Category: Allerston, C K.]] | ||
Revision as of 05:25, 9 April 2014
Structure of GAK kinase in complex with nanobody (NbGAK_4)
Template:ABSTRACT PUBMED 24438162
Function
[GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.[1]
About this Structure
4c58 is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Chaikuad A, Keates T, Vincke C, Kaufholz M, Zenn M, Zimmermann B, Gutierrez C, Zhang RG, Hatzos-Skintges C, Joachimiak A, Muyldermans S, Herberg FW, Knapp S, Muller S. Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies. Biochem J. 2014 Apr 1;459(1):59-69. doi: 10.1042/BJ20131399. PMID:24438162 doi:https://dx.doi.org/10.1042/BJ20131399
