4k1l: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 beta-HSD1 inhibitors for the treatment of diabetes===

~~The~~ entry ~~4k1l is ON HOLD until Apr 05 2015~~

==Disease==

[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[http://omim.org/entry/604931 604931]]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).

~~Authors~~: ~~Loenze, P~~.~~, Schimanski~~-~~Breves, S~~., ~~Von der Heyden~~, ~~C., Engel, C.K~~.

==Function==

[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

~~Description~~: ~~4,4~~-~~Dioxo~~-5,~~6-dihydro-~~[1,4,3]~~oxathiazines~~, ~~a novel class of~~ 11 beta-~~HSD1 inhibitors for the treatment of diabetes~~

==About this Structure==

[[4k1l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1L OCA].

==Reference==

[[Category: 11-beta-hydroxysteroid dehydrogenase]]

[[Category: Engel, C K.]]

[[Category: Heyden, C Von der.]]

[[Category: Loenze, P.]]

[[Category: Schimanski-Breves, S.]]

[[Category: 11-beta-hsd1]]

[[Category: 11-beta-hydroxysteroid dehydrogenase 1]]

[[Category: 11-dh]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

[[Category: Short chain dehydrogenase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4k1l|  PDB=4k1l  |  SCENE=  }}
+===4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 beta-HSD1 inhibitors for the treatment of diabetes===
+{{ABSTRACT_PUBMED_23845218}}
-The entry 4k1l is ON HOLD  until Apr 05 2015
+==Disease==
+[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[http://omim.org/entry/604931 604931]]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
-Authors: Loenze, P., Schimanski-Breves, S., Von der Heyden, C., Engel, C.K.
+==Function==
+[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
-Description: 4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 beta-HSD1 inhibitors for the treatment of diabetes
+==About this Structure==
+[[4k1l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1L OCA].
+==Reference==
+<ref group="xtra">PMID:023845218</ref><references group="xtra"/><references/>
+[[Category: 11-beta-hydroxysteroid dehydrogenase]]
+[[Category: Engel, C K.]]
+[[Category: Heyden, C Von der.]]
+[[Category: Loenze, P.]]
+[[Category: Schimanski-Breves, S.]]
+[[Category: 11-beta-hsd1]]
+[[Category: 11-beta-hydroxysteroid dehydrogenase 1]]
+[[Category: 11-dh]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+[[Category: Short chain dehydrogenase]]