4omd: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4omd|  PDB=4omd  |  SCENE=  }}
===X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba===
{{ABSTRACT_PUBMED_24666235}}


The entry 4omd is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/FURIN_HUMAN FURIN_HUMAN]] Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.<ref>PMID:7690548</ref>  


Authors: Dahms, S.O., Than, M.E.
==About this Structure==
[[4omd]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMD OCA].  


Description: X-ray structure of human furin in complex with the competitive inhibitor Phac-RVRR-Amba
==Reference==
<ref group="xtra">PMID:024666235</ref><references group="xtra"/><references/>
[[Category: Furin]]
[[Category: Dahms, S O.]]
[[Category: Than, M E.]]
[[Category: Competitive inhibitor]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Pro-protein convertase]]
[[Category: Protease-inhibitor complex]]
[[Category: Serine protease]]

Revision as of 06:24, 9 April 2014

Template:STRUCTURE 4omd

X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba

Template:ABSTRACT PUBMED 24666235

Function

[FURIN_HUMAN] Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.[1]

About this Structure

4omd is a 12 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Dahms SO, Hardes K, Becker GL, Steinmetzer T, Brandstetter H, Than ME. X-ray Structures of Human Furin in Complex with Competitive Inhibitors. ACS Chem Biol. 2014 Apr 1. PMID:24666235 doi:https://dx.doi.org/10.1021/cb500087x
  1. ↑ Takahashi S, Kasai K, Hatsuzawa K, Kitamura N, Misumi Y, Ikehara Y, Murakami K, Nakayama K. A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells. Biochem Biophys Res Commun. 1993 Sep 15;195(2):1019-26. PMID:7690548 doi:https://dx.doi.org/10.1006/bbrc.1993.2146

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