4hnd: Difference between revisions
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{{STRUCTURE_4hnd| PDB=4hnd | SCENE= }} | |||
===Crystal stucture of the catalytic domain of Selenomethionine substituted human PI4KIIalpha in complex with ADP=== | |||
{{ABSTRACT_PUBMED_24675427}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN]] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking. | |||
==About this Structure== | |||
[[4hnd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HND OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024675427</ref><references group="xtra"/><references/> | |||
[[Category: 1-phosphatidylinositol 4-kinase]] | |||
[[Category: Chen, C.]] | |||
[[Category: Sun, F.]] | |||
[[Category: Zhai, Y.]] | |||
[[Category: Zhang, K.]] | |||
[[Category: Zhou, Q.]] | |||
[[Category: Atp binding]] | |||
[[Category: Lipid kinase]] | |||
[[Category: Membrane anchoring]] | |||
[[Category: Palmitoylation]] | |||
[[Category: Pi3k/pi4k kinase]] | |||
[[Category: Transferase]] | |||
Revision as of 06:29, 9 April 2014
Crystal stucture of the catalytic domain of Selenomethionine substituted human PI4KIIalpha in complex with ADP
Template:ABSTRACT PUBMED 24675427
Function
[P4K2A_HUMAN] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.
About this Structure
4hnd is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Zhou Q, Li J, Yu H, Zhai Y, Gao Z, Liu Y, Pang X, Zhang L, Schulten K, Sun F, Chen C. Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIalpha. Nat Commun. 2014 Mar 28;5:3552. doi: 10.1038/ncomms4552. PMID:24675427 doi:https://dx.doi.org/10.1038/ncomms4552
