4bpj: Difference between revisions
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{{STRUCTURE_4bpj| PDB=4bpj | SCENE= }} | |||
===Mcl-1 bound to alpha beta Puma BH3 peptide 3=== | |||
{{ABSTRACT_PUBMED_23929624}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MCL1_MOUSE MCL1_MOUSE]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. | |||
==About this Structure== | |||
[[4bpj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPJ OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023929624</ref><references group="xtra"/><references/> | |||
[[Category: Checco, J W.]] | |||
[[Category: Fairlie, W D.]] | |||
[[Category: Gellman, S H.]] | |||
[[Category: Lee, E F.]] | |||
[[Category: Smith, B J.]] | |||
[[Category: Apoptosis]] | |||
[[Category: Bim]] | |||
[[Category: Chimera]] | |||
Revision as of 06:32, 9 April 2014
Mcl-1 bound to alpha beta Puma BH3 peptide 3
Template:ABSTRACT PUBMED 23929624
Function
[MCL1_MOUSE] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
About this Structure
4bpj is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Smith BJ, Lee EF, Checco JW, Evangelista M, Gellman SH, Fairlie WD. Structure-guided rational design of alpha/beta-peptide foldamers with high affinity for BCL-2 family prosurvival proteins. Chembiochem. 2013 Sep 2;14(13):1564-72. doi: 10.1002/cbic.201300351. Epub 2013, Aug 8. PMID:23929624 doi:https://dx.doi.org/10.1002/cbic.201300351
