Sandbox Reserved 911: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 6: | Line 6: | ||
Fatty acid amide hydrolase (FAAH) degrades fatty acid amides (FAAs) to terminate their signaling activity <ref name="1MT5">PMID:12459591</ref>. A serine hydrolase from the [http://en.wikipedia.org/wiki/Amidase Amidase] signature superfamily of enzymes ([http://proteopedia.org/wiki/index.php/Category:Amidase other amidases]), FAAH degrades endocannabinoid signaling lipids, molecules associated with pain relief <ref name="2WAP">PMID:19389627</ref>. Because [http://en.wikipedia.org/wiki/Endocannabinoid_system endocannabinoids] are lipid molecules, they cannot be compartmentalized in vesicles (the degradation method for other neurotransmitters) and must instead be degraded in the bilayer of the cell membrane. FAAH is an [http://stevens.scripps.edu/images/faah_fig2.jpg integral membrane protein] that degrades FAAs as they enter the membrane bilayer, allowing the cell to terminate the activity of signaling molecules that cannot be contained within a vesicle for degredation <ref name="1MT5"/>. Current FAAH research aims to find inhibitors for the enzyme, which would prolong the pain alleviation provided by endocannabinoid molecules <ref name="2WAP"/>. | Fatty acid amide hydrolase (FAAH) degrades fatty acid amides (FAAs) to terminate their signaling activity <ref name="1MT5">PMID:12459591</ref>. A serine hydrolase from the [http://en.wikipedia.org/wiki/Amidase Amidase] signature superfamily of enzymes ([http://proteopedia.org/wiki/index.php/Category:Amidase other amidases]), FAAH degrades endocannabinoid signaling lipids, molecules associated with pain relief <ref name="2WAP">PMID:19389627</ref>. Because [http://en.wikipedia.org/wiki/Endocannabinoid_system endocannabinoids] are lipid molecules, they cannot be compartmentalized in vesicles (the degradation method for other neurotransmitters) and must instead be degraded in the bilayer of the cell membrane. FAAH is an [http://stevens.scripps.edu/images/faah_fig2.jpg integral membrane protein] that degrades FAAs as they enter the membrane bilayer, allowing the cell to terminate the activity of signaling molecules that cannot be contained within a vesicle for degredation <ref name="1MT5"/>. Current FAAH research aims to find inhibitors for the enzyme, which would prolong the pain alleviation provided by endocannabinoid molecules <ref name="2WAP"/>. | ||
[[Image:1MT5.png|400 px|left|thumb|FAAH Monomer Subunit; Enzyme in teal, Ligand in pink. FAAH [http://proteopedia.org/wiki/index.php/1mt5 Crystal Structure]]] | [[Image:1MT5.png|400 px|left|thumb|FAAH Monomer Subunit; Enzyme in teal, Ligand in pink. FAAH [http://proteopedia.org/wiki/index.php/1mt5 Crystal Structure.]]] | ||
==Hydrolase Information== | ==Hydrolase Information== | ||
