Sandbox reserved 919: Difference between revisions
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==Introduction to hormone-sensitive lipase== | ==Introduction to hormone-sensitive lipase== | ||
[[Image:HPL_Movie0006.png|300 px|left|thumb|Hormone-Sensitive Lipase]] | [[Image:HPL_Movie0006.png|300 px|left|thumb|Hormone-Sensitive Lipase from [[3dnm]]]] | ||
Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] (HSL) represent a class of [http://en.wikipedia.org/wiki/Esterase esterases] within the [http://www.proteopedia.org/wiki/index.php/Hydrolase hydrolase] family that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin]. HSL is clinically relevant because the mobilization of fats in cells is directly related to fat accumulation seen in [http://en.wikipedia.org/wiki/Atherosclerosis artherosclerosis], [http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 type 2 diabetes], and [http://en.wikipedia.org/wiki/Obesity obesity]. Investigation of HSL's structure and function could provide a better clinical understanding of these diseases. <ref name= "Yeaman">PMID:14725507</ref> | Hormone-sensitive [http://proteopedia.org/wiki/index.php/Lipase lipases] (HSL) represent a class of [http://en.wikipedia.org/wiki/Esterase esterases] within the [http://www.proteopedia.org/wiki/index.php/Hydrolase hydrolase] family that catalyzes the cleavage of ester bonds in fatty acid molecules when stimulated by a hormone. The activation and mobilization of these hormone-sensitive lipases can be triggered by various [http://en.wikipedia.org/wiki/Catecholamine catecholamines] and inhibited by [http://www.proteopedia.org/wiki/index.php/Insulin insulin]. HSL is clinically relevant because the mobilization of fats in cells is directly related to fat accumulation seen in [http://en.wikipedia.org/wiki/Atherosclerosis artherosclerosis], [http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 type 2 diabetes], and [http://en.wikipedia.org/wiki/Obesity obesity]. Investigation of HSL's structure and function could provide a better clinical understanding of these diseases. <ref name= "Yeaman">PMID:14725507</ref> | ||
