1ow3: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "1ow3" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_1ow3| PDB=1ow3 | SCENE= }} | {{STRUCTURE_1ow3| PDB=1ow3 | SCENE= }} | ||
===Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP=== | ===Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP=== | ||
{{ABSTRACT_PUBMED_11927263}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RHG01_HUMAN RHG01_HUMAN]] GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[1ow3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[1ow3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OW3 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011927263</ref><references group="xtra"/> | <ref group="xtra">PMID:011927263</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Eccleston, J F.]] | [[Category: Eccleston, J F.]] | ||
[[Category: Gamblin, S J.]] | [[Category: Gamblin, S J.]] | ||
