2ymy: Difference between revisions
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{{STRUCTURE_2ymy| PDB=2ymy | SCENE= }} | |||
===Structure of the murine Nore1-Sarah domain=== | |||
{{ABSTRACT_PUBMED_23331050}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/RASF5_MOUSE RASF5_MOUSE]] Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.<ref>PMID:11864565</ref> | |||
==About this Structure== | |||
[[2ymy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMY OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023331050</ref><references group="xtra"/><references/> | |||
[[Category: Lk3 transgenic mice]] | |||
[[Category: Aruxandei, D C.]] | |||
[[Category: Herrmann, C.]] | |||
[[Category: Hofmann, E.]] | |||
[[Category: Makbul, C.]] | |||
[[Category: Schwarz, D.]] | |||
[[Category: Wolf, E.]] | |||
[[Category: Apoptosis]] | |||
[[Category: Coiled-coil]] | |||
[[Category: Ras association domain family]] | |||
[[Category: Tumor suppressor]] | |||
Revision as of 08:36, 16 April 2014
Structure of the murine Nore1-Sarah domain
Template:ABSTRACT PUBMED 23331050
Function
[RASF5_MOUSE] Potental tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis.[1]
About this Structure
2ymy is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
Reference
- Makbul C, Constantinescu Aruxandei D, Hofmann E, Schwarz D, Wolf E, Herrmann C. Structural and Thermodynamic Characterization of Nore1-SARAH: A Small, Helical Module Important in Signal Transduction Networks. Biochemistry. 2013 Feb 12;52(6):1045-54. doi: 10.1021/bi3014642. Epub 2013 Jan, 30. PMID:23331050 doi:https://dx.doi.org/10.1021/bi3014642
