4ctj: Difference between revisions
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{{STRUCTURE_4ctj| PDB=4ctj | SCENE= }} | |||
===DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 3A9=== | |||
{{ABSTRACT_PUBMED_24704437}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/A9LIE0_9FLAV A9LIE0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774] | |||
==About this Structure== | |||
[[4ctj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CTJ OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024704437</ref><references group="xtra"/><references/> | |||
[[Category: Barral, K.]] | |||
[[Category: Bricogne, G.]] | |||
[[Category: Sharff, A.]] | |||
[[Category: Antiviral screening]] | |||
[[Category: Fragment-based drug discovery]] | |||
[[Category: Ns5 methyltransferase]] | |||
[[Category: Transferase]] | |||
Revision as of 09:39, 16 April 2014
DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 3A9
Template:ABSTRACT PUBMED 24704437
Function
[A9LIE0_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774]
About this Structure
4ctj is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Coutard B, Decroly E, Li C, Sharff A, Lescar J, Bricogne G, Barral K. Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery. Antiviral Res. 2014 Apr 1. pii: S0166-3542(14)00087-4. doi:, 10.1016/j.antiviral.2014.03.013. PMID:24704437 doi:https://dx.doi.org/10.1016/j.antiviral.2014.03.013
