4o3c: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the GLUA2 ligand-binding domain in complex with L-apartate at 1.50 A resolution===

The ~~entry 4o3c~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>

~~Authors~~: ~~Krintel, C., Frydenvang, K., Kaern, A.M~~.~~, Gajhede, M~~.~~, Kastrup, J~~.S.

==About this Structure==

[[4o3c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O3C OCA].

~~Description~~: ~~Crystal structure of the GLUA2~~ ligand-binding domain in complex ~~with L-apartate at 1.50 A resolution~~

==Reference==

[[Category: Frydenvang, K.]]

[[Category: Gajhede, M.]]

[[Category: Kaern, A M.]]

[[Category: Kastrup, J S.]]

[[Category: Krintel, C.]]

[[Category: Agonist]]

[[Category: Ampa receptor ligand-binding domain]]

[[Category: Glua2]]

[[Category: Membrane protein]]

[[Category: Membrane protein-agonist complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4o3c|  PDB=4o3c  |  SCENE=  }}
+===Crystal structure of the GLUA2 ligand-binding domain in complex with L-apartate at 1.50 A resolution===
+{{ABSTRACT_PUBMED_11086992}}
-The entry 4o3c is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
-Authors: Krintel, C., Frydenvang, K., Kaern, A.M., Gajhede, M., Kastrup, J.S.
+==About this Structure==
+[[4o3c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O3C OCA].
-Description: Crystal structure of the GLUA2 ligand-binding domain in complex with L-apartate at 1.50 A resolution
+==Reference==
+<ref group="xtra">PMID:011086992</ref><references group="xtra"/><references/>
+[[Category: Frydenvang, K.]]
+[[Category: Gajhede, M.]]
+[[Category: Kaern, A M.]]
+[[Category: Kastrup, J S.]]
+[[Category: Krintel, C.]]
+[[Category: Agonist]]
+[[Category: Ampa receptor ligand-binding domain]]
+[[Category: Glua2]]
+[[Category: Membrane protein]]
+[[Category: Membrane protein-agonist complex]]