2mh2: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2===

The ~~entry 2mh2 is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/HOP2_MOUSE HOP2_MOUSE]] Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.<ref>PMID:9345291</ref> <ref>PMID:15192114</ref> <ref>PMID:16675459</ref> <ref>PMID:17639080</ref> <ref>PMID:17639081</ref> <ref>PMID:17426123</ref>

~~Authors~~: ~~Moktan, H~~.~~, Guiraldelli, M~~.F.~~, Eyter, C.A., Zhao, W., Camerini~~-~~Otero, R.D., Sung, P., Zhou, D.H., Pezza, R.J~~.

==About this Structure==

[[2mh2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH2 OCA].

~~Description~~: ~~Structural insights into the DNA recognition and~~ protein ~~interaction domains reveal fundamental homologous DNA~~ pairing ~~properties of HOP2~~

==Reference==

[[Category: Camerini-Otero, R D.]]

[[Category: Eyter, C A.]]

[[Category: Guiraldelli, M F.]]

[[Category: Moktan, H.]]

[[Category: Pezza, R J.]]

[[Category: Sung, P.]]

[[Category: Zhao, W.]]

[[Category: Zhou, D H.]]

[[Category: Dna binding protein]]

[[Category: Homologous pairing protein]]

[[Category: Homologous recombination]]

[[Category: Meiosis]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2mh2|  PDB=2mh2  |  SCENE=  }}
+===Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2===
-The entry 2mh2 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/HOP2_MOUSE HOP2_MOUSE]] Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.<ref>PMID:9345291</ref> <ref>PMID:15192114</ref> <ref>PMID:16675459</ref> <ref>PMID:17639080</ref> <ref>PMID:17639081</ref> <ref>PMID:17426123</ref>
-Authors: Moktan, H., Guiraldelli, M.F., Eyter, C.A., Zhao, W., Camerini-Otero, R.D., Sung, P., Zhou, D.H., Pezza, R.J.
+==About this Structure==
+[[2mh2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH2 OCA].
-Description: Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Camerini-Otero, R D.]]
+[[Category: Eyter, C A.]]
+[[Category: Guiraldelli, M F.]]
+[[Category: Moktan, H.]]
+[[Category: Pezza, R J.]]
+[[Category: Sung, P.]]
+[[Category: Zhao, W.]]
+[[Category: Zhou, D H.]]
+[[Category: Dna binding protein]]
+[[Category: Homologous pairing protein]]
+[[Category: Homologous recombination]]
+[[Category: Meiosis]]