4n1u: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Struture of human MTH1 in complex with TH588===

~~The entry 4n1u is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>

~~Authors~~: ~~Berntsson, R.P-A~~.~~, Jemth, A~~.~~, Gustafsson, R~~.~~, Svensson, L.M., Helleday, T., Stenmark, P~~.

==About this Structure==

[[4n1u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1U OCA].

~~Description~~: ~~Struture of human MTH1 in~~ complex ~~with TH588~~

==Reference==

[[Category: Berntsson, R P-A.]]

[[Category: Gustafsson, R.]]

[[Category: Helleday, T.]]

[[Category: Jemth, A.]]

[[Category: Stenmark, P.]]

[[Category: Svensson, L M.]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Oxidised nucleotide degradation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4n1u|  PDB=4n1u  |  SCENE=  }}
+===Struture of human MTH1 in complex with TH588===
-The entry 4n1u is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
-Authors: Berntsson, R.P-A., Jemth, A., Gustafsson, R., Svensson, L.M., Helleday, T., Stenmark, P.
+==About this Structure==
+[[4n1u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1U OCA].
-Description: Struture of human MTH1 in complex with TH588
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Berntsson, R P-A.]]
+[[Category: Gustafsson, R.]]
+[[Category: Helleday, T.]]
+[[Category: Jemth, A.]]
+[[Category: Stenmark, P.]]
+[[Category: Svensson, L M.]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Oxidised nucleotide degradation]]