4p6x: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain===

~~The~~ entry ~~4p6x~~ is ~~ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.

~~Authors~~: He, Y., ~~Zhou, X~~.E.~~, Tolbert, W~~.D.~~, Powell, K~~.~~, Melcher, K~~.~~, Xu, H~~.E.

==Function==

[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>

~~Description~~: ~~Crystal Structure of cortisol~~-~~bound glucocorticoid~~ receptor ~~ligand binding domain~~

==About this Structure==

[[4p6x]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6X OCA].

==Reference==

[[Category: He, Y.]]

[[Category: Melcher, K.]]

[[Category: Powell, K.]]

[[Category: Tolbert, W D.]]

[[Category: Xu, H E.]]

[[Category: Zhou, X E.]]

[[Category: Cortisol]]

[[Category: Glucocorticoid receptor]]

[[Category: Hormone-hormone receptor complex]]

[[Category: Potency]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4p6x|  PDB=4p6x  |  SCENE=  }}
+===Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain===
-The entry 4p6x is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[http://omim.org/entry/138040 138040]]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>  [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
-Authors: He, Y., Zhou, X.E., Tolbert, W.D., Powell, K., Melcher, K., Xu, H.E.
+==Function==
+[[http://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>  [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
-Description: Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain
+==About this Structure==
+[[4p6x]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6X OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: He, Y.]]
+[[Category: Melcher, K.]]
+[[Category: Powell, K.]]
+[[Category: Tolbert, W D.]]
+[[Category: Xu, H E.]]
+[[Category: Zhou, X E.]]
+[[Category: Cortisol]]
+[[Category: Glucocorticoid receptor]]
+[[Category: Hormone-hormone receptor complex]]
+[[Category: Potency]]