1prv: Difference between revisions

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~~[[Image:1prv.png|left|200px]]~~

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~~The line below this paragraph, containing "STRUCTURE_1prv", creates the "Structure Box" on the page.~~

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

~~or leave the SCENE parameter empty for the default display.~~

~~-->~~

===PURINE REPRESSOR DNA-BINDING DOMAIN DNA BINDING===

==Function==

~~<!--~~

[[http://www.uniprot.org/uniprot/PURR_ECOLI PURR_ECOLI]] Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region of pur regulon genes. The consensus binding sequence is 5'-ACGCAAACGTTTTCNT-3'. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.<ref>PMID:2404765</ref> <ref>PMID:2211500</ref> <ref>PMID:1400170</ref> <ref>PMID:14741201</ref>

~~The line below this paragraph, {{ABSTRACT_PUBMED_8591032}}, adds the Publication Abstract to the page~~

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 8591032 is~~ the ~~PubMed ID number~~.

-->

~~{{ABSTRACT_PUBMED_8591032}}~~

==About this Structure==

[[1prv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRV OCA].

==See Also==

*[[Purine repressor|Purine repressor]]

==Reference==

[[Category: Escherichia coli]]

[[Category: Brennan, R G.]]

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@@ Line 1: / Line 1: @@
-[[Image:1prv.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_1prv", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_1prv|  PDB=1prv  |  SCENE=  }}
 ===PURINE REPRESSOR DNA-BINDING DOMAIN DNA BINDING===
+{{ABSTRACT_PUBMED_8591032}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/PURR_ECOLI PURR_ECOLI]] Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region of pur regulon genes. The consensus binding sequence is 5'-ACGCAAACGTTTTCNT-3'. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.<ref>PMID:2404765</ref> <ref>PMID:2211500</ref> <ref>PMID:1400170</ref> <ref>PMID:14741201</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_8591032}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 8591032 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_8591032}}
 ==About this Structure==
 [[1prv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRV OCA].
+==See Also==
+*[[Purine repressor|Purine repressor]]
 ==Reference==
-<ref group="xtra">PMID:008591032</ref><references group="xtra"/>
+<ref group="xtra">PMID:008591032</ref><references group="xtra"/><references/>
 [[Category: Escherichia coli]]
 [[Category: Brennan, R G.]]