1e4e: Difference between revisions

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[[Image:1e4e.png|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_1e4e", creates the "Structure Box" on the page.
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{{STRUCTURE_1e4e|  PDB=1e4e  |  SCENE=  }}  
{{STRUCTURE_1e4e|  PDB=1e4e  |  SCENE=  }}  
===D-ALANYL-D-LACATE LIGASE===
===D-ALANYL-D-LACATE LIGASE===
{{ABSTRACT_PUBMED_10908650}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/VANA_ENTFC VANA_ENTFC]] Required for high-level resistance to glycopeptide antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; produces a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin or teicoplanin binding.<ref>PMID:1931965</ref> 
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{{ABSTRACT_PUBMED_10908650}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:010908650</ref><ref group="xtra">PMID:016779845</ref><references group="xtra"/>
<ref group="xtra">PMID:010908650</ref><references group="xtra"/><references/>
[[Category: Enterococcus faecium]]
[[Category: Enterococcus faecium]]
[[Category: Roper, D I.]]
[[Category: Roper, D I.]]

Revision as of 10:48, 16 April 2014

Template:STRUCTURE 1e4e

D-ALANYL-D-LACATE LIGASE

Template:ABSTRACT PUBMED 10908650

Function

[VANA_ENTFC] Required for high-level resistance to glycopeptide antibiotics. D-Ala--D-Ala ligase of altered specificity which catalyzes ester bond formation between D-Ala and various D-hydroxy acids; produces a peptidoglycan which does not terminate in D-alanine but in D-lactate, thus preventing vancomycin or teicoplanin binding.[1]

About this Structure

1e4e is a 2 chain structure with sequence from Enterococcus faecium. Full crystallographic information is available from OCA.

Reference

  1. Roper DI, Huyton T, Vagin A, Dodson G. The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA). Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8921-5. PMID:10908650 doi:https://dx.doi.org/10.1073/pnas.150116497
  1. ↑ Bugg TD, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT. Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry. 1991 Oct 29;30(43):10408-15. PMID:1931965

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