1muf: Difference between revisions

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~~[[Image:1muf.png|left|200px]]~~

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~~The line below this paragraph, containing "STRUCTURE_1muf", creates the "Structure Box" on the page.~~

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

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===Structure of histone H3 K4-specific methyltransferase SET7/9===

==Function==

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[[http://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN]] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref> <ref>PMID:15099517</ref> <ref>PMID:16141209</ref> <ref>PMID:17108971</ref> <ref>PMID:12540855</ref> <ref>PMID:15525938</ref>

~~The line below this paragraph, {{ABSTRACT_PUBMED_12389038}}, adds~~ the ~~Publication Abstract~~ to the ~~page~~

(as ~~it appears on PubMed at http:~~/~~/www~~.~~pubmed.gov)~~, ~~where 12389038 is~~ the ~~PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_12389038}}~~

==About this Structure==

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==Reference==

[[Category: Histone-lysine N-methyltransferase]]

[[Category: Homo sapiens]]

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@@ Line 1: / Line 1: @@
-[[Image:1muf.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_1muf", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_1muf|  PDB=1muf  |  SCENE=  }}
 ===Structure of histone H3 K4-specific methyltransferase SET7/9===
+{{ABSTRACT_PUBMED_12389038}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN]] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref> <ref>PMID:15099517</ref> <ref>PMID:16141209</ref> <ref>PMID:17108971</ref> <ref>PMID:12540855</ref> <ref>PMID:15525938</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_12389038}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 12389038 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_12389038}}
 ==About this Structure==
@@ Line 22: / Line 10: @@
 ==Reference==
-<ref group="xtra">PMID:012389038</ref><references group="xtra"/>
+<ref group="xtra">PMID:012389038</ref><references group="xtra"/><references/>
 [[Category: Histone-lysine N-methyltransferase]]
 [[Category: Homo sapiens]]