Sandbox 126: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 72: | Line 72: | ||
<scene name='37/372726/3zfz_with_muramic_acid/1'>PBP2a in complex with Ceftaroline (3zfz)</scene> | <scene name='37/372726/3zfz_with_muramic_acid/1'>PBP2a in complex with Ceftaroline (3zfz)</scene> | ||
In addition to TP domain of PBP2a, there is an allosteric domain in which the distance between the the active site and the allosteric site is 60Å. Allosteric site serves as a binding site for the substrate peptidoglycan. When the substrate binds to the allosteric site, a conformational change occurs at the active site, opening it and allowing catalytic action to occur. The medicine, <scene name='37/372726/Ceftaroline/2'>ceftaroline</scene>, mimics the substrate at the allosteric site opening the active site, allowing ceftaroline to enter and bind noncovalently. | In addition to TP domain of PBP2a, there is an allosteric domain in which the distance between the the active site and the allosteric site is 60Å. Allosteric site serves as a binding site for the substrate peptidoglycan. When the substrate binds to the | ||
<scene name='37/372726/3zfz_allosteric_site/1'>allosteric site</scene>, a conformational change occurs at the active site, opening it and allowing catalytic action to occur. The medicine, <scene name='37/372726/Ceftaroline/2'>ceftaroline</scene>, mimics the substrate at the allosteric site opening the active site, allowing ceftaroline to enter and bind noncovalently. | |||
<scene name='37/372726/3zfz_with_ceftaroline/1'>PBP2a in complex with ceftaroline</scene> | <scene name='37/372726/3zfz_with_ceftaroline/1'>PBP2a in complex with ceftaroline</scene> | ||
