4imt: Difference between revisions
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{{STRUCTURE_4imt| PDB=4imt | SCENE= }} | {{STRUCTURE_4imt| PDB=4imt | SCENE= }} | ||
===Structure of | ===Structure of rat neuronal nitric oxide synthase in complex with 6,6'-((4-(3-aminopropyl)-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine)=== | ||
{{ABSTRACT_PUBMED_23451760}} | {{ABSTRACT_PUBMED_23451760}} | ||
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==About this Structure== | ==About this Structure== | ||
[[4imt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4imt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMT OCA]. | ||
[[Category: | |||
==See Also== | |||
*[[Nitric Oxide Synthase|Nitric Oxide Synthase]] | |||
==Reference== | |||
<ref group="xtra">PMID:023451760</ref><references group="xtra"/><references/> | |||
[[Category: Buffalo rat]] | |||
[[Category: Li, H.]] | [[Category: Li, H.]] | ||
[[Category: Poulos, T L.]] | [[Category: Poulos, T L.]] | ||
[[Category: Oxidoreductase nitric oxide synthase]] | [[Category: Oxidoreductase nitric oxide synthase]] | ||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
Revision as of 06:38, 23 April 2014
Structure of rat neuronal nitric oxide synthase in complex with 6,6'-((4-(3-aminopropyl)-1,3-phenylene)bis(ethane-2,1-diyl))bis(4-methylpyridin-2-amine)
Template:ABSTRACT PUBMED 23451760
Function
[NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
About this Structure
4imt is a 2 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.
See Also
Reference
- Huang H, Li H, Martasek P, Roman LJ, Poulos TL, Silverman RB. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase. J Med Chem. 2013 Apr 11;56(7):3024-32. doi: 10.1021/jm4000984. Epub 2013 Mar 28. PMID:23451760 doi:https://dx.doi.org/10.1021/jm4000984
