3n09: Difference between revisions
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{{STRUCTURE_3n09| PDB=3n09 | SCENE= }} | {{STRUCTURE_3n09| PDB=3n09 | SCENE= }} | ||
===Atomic model of an infectious rotavirus particle=== | ===Atomic model of an infectious rotavirus particle=== | ||
{{ABSTRACT_PUBMED_21157433}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/VP6_ROTRH VP6_ROTRH]] Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP (By similarity). | |||
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==About this Structure== | ==About this Structure== | ||
[[3n09]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3n09]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Rotrh Rotrh] and [http://en.wikipedia.org/wiki/Simian_rotavirus_a_strain_rrv Simian rotavirus a strain rrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N09 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021157433</ref><references group="xtra"/> | <ref group="xtra">PMID:021157433</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Rotrh]] | ||
[[Category: Simian rotavirus a]] | [[Category: Simian rotavirus a strain rrv]] | ||
[[Category: Chen, J Z.]] | [[Category: Chen, J Z.]] | ||
[[Category: Dormitzer, P R.]] | [[Category: Dormitzer, P R.]] | ||
Revision as of 06:47, 23 April 2014
Atomic model of an infectious rotavirus particle
Template:ABSTRACT PUBMED 21157433
Function
[VP6_ROTRH] Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP (By similarity).
About this Structure
3n09 is a 15 chain structure with sequence from Rotrh and Simian rotavirus a strain rrv. Full crystallographic information is available from OCA.
Reference
- Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC. Atomic model of an infectious rotavirus particle. EMBO J. 2011 Jan 19;30(2):408-16. Epub 2010 Dec 14. PMID:21157433 doi:10.1038/emboj.2010.322
