3d9e: Difference between revisions
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{{STRUCTURE_3d9e| PDB=3d9e | SCENE= }} | {{STRUCTURE_3d9e| PDB=3d9e | SCENE= }} | ||
===Nitroalkane oxidase: active site mutant D402N crystallized with 1-nitrooctane=== | ===Nitroalkane oxidase: active site mutant D402N crystallized with 1-nitrooctane=== | ||
{{ABSTRACT_PUBMED_19265437}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NAO_FUSOX NAO_FUSOX]] Catalyzes the oxidative denitrification of neutral nitroalkanes, including 3-nitro-2-pentanol, 1-nitropropane, 2-nitropropane, nitroethane and nitrocyclohexane, and may thereby protect the organism against toxic compounds. Has no detectable acyl-CoA dehydrogenase activity.<ref>PMID:11867731</ref> <ref>PMID:22538</ref> <ref>PMID:16430210</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3d9e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3d9e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Fusox Fusox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9E OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019265437</ref>< | <ref group="xtra">PMID:019265437</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Fusox]] | ||
[[Category: Nitroalkane oxidase]] | [[Category: Nitroalkane oxidase]] | ||
[[Category: Bozinovski, D M.]] | [[Category: Bozinovski, D M.]] | ||
Revision as of 06:53, 23 April 2014
Nitroalkane oxidase: active site mutant D402N crystallized with 1-nitrooctane
Template:ABSTRACT PUBMED 19265437
Function
[NAO_FUSOX] Catalyzes the oxidative denitrification of neutral nitroalkanes, including 3-nitro-2-pentanol, 1-nitropropane, 2-nitropropane, nitroethane and nitrocyclohexane, and may thereby protect the organism against toxic compounds. Has no detectable acyl-CoA dehydrogenase activity.[1] [2] [3]
About this Structure
3d9e is a 4 chain structure with sequence from Fusox. Full crystallographic information is available from OCA.
Reference
- Heroux A, Bozinovski DM, Valley MP, Fitzpatrick PF, Orville AM. Crystal Structures of Intermediates in the Nitroalkane Oxidase Reaction (dagger) (double dagger). Biochemistry. 2009 Mar 27. PMID:19265437 doi:10.1021/bi8023042
- ↑ Daubner SC, Gadda G, Valley MP, Fitzpatrick PF. Cloning of nitroalkane oxidase from Fusarium oxysporum identifies a new member of the acyl-CoA dehydrogenase superfamily. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2702-7. Epub 2002 Feb 26. PMID:11867731 doi:https://dx.doi.org/10.1073/pnas.052527799
- ↑ Kido T, Hashizume K, Soda K. Purification and properties of nitroalkane oxidase from Fusarium oxysporum. J Bacteriol. 1978 Jan;133(1):53-8. PMID:22538
- ↑ Nagpal A, Valley MP, Fitzpatrick PF, Orville AM. Crystal structures of nitroalkane oxidase: insights into the reaction mechanism from a covalent complex of the flavoenzyme trapped during turnover. Biochemistry. 2006 Jan 31;45(4):1138-50. PMID:16430210 doi:10.1021/bi051966w
