4pxt: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4pxt| PDB=4pxt | SCENE= }} | |||
===Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers=== | |||
{{ABSTRACT_PUBMED_24714498}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/KL61_DROME KL61_DROME]] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function. | |||
==About this Structure== | |||
[[4pxt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PXT OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024714498</ref><references group="xtra"/><references/> | |||
[[Category: Al-Bassam, J.]] | |||
[[Category: Nithianantham, S.]] | |||
[[Category: Scholey, J E.]] | |||
[[Category: Scholey, J M.]] | |||
[[Category: Anti-parallel four-helix bundle]] | |||
[[Category: Bipolar assembly domain of kinesin-5]] | |||
[[Category: Bipolar tetramer]] | |||
[[Category: Cell cycle]] | |||
[[Category: Coiled-coil]] | |||
[[Category: Crosslinking adjacent microtubules into bundles throughout the mitotic spindle]] | |||
[[Category: Kinesin-5 functions via a sliding filament mechanism]] | |||
[[Category: Microtubule]] | |||
Revision as of 07:40, 23 April 2014
Structural basis for the assembly of the mitotic motor kinesin-5 into bipolar tetramers
Template:ABSTRACT PUBMED 24714498
Function
[KL61_DROME] Important role in mitotic dividing cells. Microtubule motor required for spindle body separation. Slow plus-end directed microtubule motor capable of cross-linking and sliding apart antiparallel microtubules, thereby pushing apart the associated spindle poles during spindle assembly and function.
About this Structure
4pxt is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Scholey JE, Nithianantham S, Scholey JM, Al-Bassam J. Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers. Elife. 2014 Apr 8;3:e02217. doi: 10.7554/eLife.02217. PMID:24714498
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Al-Bassam, J.
- Nithianantham, S.
- Scholey, J E.
- Scholey, J M.
- Anti-parallel four-helix bundle
- Bipolar assembly domain of kinesin-5
- Bipolar tetramer
- Cell cycle
- Coiled-coil
- Crosslinking adjacent microtubules into bundles throughout the mitotic spindle
- Kinesin-5 functions via a sliding filament mechanism
- Microtubule
