1sr7: Difference between revisions
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{{STRUCTURE_1sr7| PDB=1sr7 | SCENE= }} | {{STRUCTURE_1sr7| PDB=1sr7 | SCENE= }} | ||
===Progesterone Receptor Hormone Binding Domain with Bound Mometasone Furoate=== | ===Progesterone Receptor Hormone Binding Domain with Bound Mometasone Furoate=== | ||
{{ABSTRACT_PUBMED_15189034}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[1sr7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SR7 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:015189034</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Austin, R J.]] | [[Category: Austin, R J.]] | ||
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[[Category: Progesterone]] | [[Category: Progesterone]] | ||
[[Category: Progesterone receptor]] | [[Category: Progesterone receptor]] | ||
[[Category: Transcription]] | |||