1zvd: Difference between revisions

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[[Image:1zvd.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_1zvd", creates the "Structure Box" on the page.
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{{STRUCTURE_1zvd|  PDB=1zvd  |  SCENE=  }}  
{{STRUCTURE_1zvd|  PDB=1zvd  |  SCENE=  }}  
===Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain===
===Regulation of Smurf2 Ubiquitin Ligase Activity by Anchoring the E2 to the HECT domain===
{{ABSTRACT_PUBMED_16061177}}


 
==Function==
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[[http://www.uniprot.org/uniprot/SMUF2_HUMAN SMUF2_HUMAN]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.<ref>PMID:11389444</ref> <ref>PMID:12717440</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_16061177}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16061177}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:016061177</ref><references group="xtra"/>
<ref group="xtra">PMID:016061177</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Briant, D J.]]
[[Category: Briant, D J.]]
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