2e2c: Difference between revisions

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[[Image:2e2c.png|left|200px]]
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{{STRUCTURE_2e2c|  PDB=2e2c  |  SCENE=  }}  
{{STRUCTURE_2e2c|  PDB=2e2c  |  SCENE=  }}  
===E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS===
===E2-C, AN UBIQUITIN CONJUGATING ENZYME REQUIRED FOR THE DESTRUCTION OF MITOTIC CYCLINS===
{{ABSTRACT_PUBMED_10350465}}


==Function==
[[http://www.uniprot.org/uniprot/UBE2C_SPISO UBE2C_SPISO]] Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that is essential for the transition from metaphase to anaphase in mitosis. Involved in both degradation of proteins responsible for maintaining sister chromatid cohesion at the onset of anaphase and of mitotic cyclins A and B at the exit of mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit (By similarity).


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==About this Structure==
The line below this paragraph, {{ABSTRACT_PUBMED_10350465}}, adds the Publication Abstract to the page
[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entries  and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA].
(as it appears on PubMed at http://www.pubmed.gov), where 10350465 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10350465}}


==About this Structure==
==See Also==
[[2e2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Spisula_solidissima Spisula solidissima]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e2c 1e2c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2C OCA].
*[[Ubiquitin conjugating enzyme|Ubiquitin conjugating enzyme]]


==Reference==
==Reference==
<ref group="xtra">PMID:010350465</ref><references group="xtra"/>
<ref group="xtra">PMID:010350465</ref><references group="xtra"/><references/>
[[Category: Spisula solidissima]]
[[Category: Spisula solidissima]]
[[Category: Ubiquitin--protein ligase]]
[[Category: Ubiquitin--protein ligase]]
Retrieved from "https://proteopedia.org/2e2c"